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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > PiroxicamCAS：36322-90-4
Molecular Formula：C15H13N3O4S
Molecular Weight：331.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 36322-90-4 |
| Name | Piroxicam |
| Molecular Formula | C15H13N3O4S |
| Molecular Weight | 331.35 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 252-974-3 |
| MDL | MFCD00057317 |
| SMILES | O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=CC=C3 |
| InChIKey | QYSPLQLAKJAUJT-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) |
| PubChem CID | 54676228 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Piroxicam is a non-steroidal anti-inflammatory agent that inhibits COX activity |
| Biological Activity | Piroxicam 是一种非甾体抗炎剂，能够抑制 COX 的活性，对人单核细胞 COX-1 和 COX-2 的 IC50 值分别为 47 和 25 μM。[1-3] |
| Data Literature Source | [1]. Kato M，et al. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 2001 Dec;53(12):1679-85. [2]. Mohammed SI，et al. Effects of the cyclooxygenase inhibitor，piroxicam，on tumor response，apoptosis，and angiogenesis in a canine model of human invasive urinary bladder cancer. Cancer Res. 2002 Jan 15;62(2):356-8. [3]. Silva J，et al. Synergistic Effect of Carboplatin and Piroxicam on Two Bladder Cancer Cell Lines. Anticancer Res. 2017 Apr;37(4):1737-1745 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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