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Parthenolide

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Cat.No：IP0090 Solarbio

CAS：20554-84-1

Molecular Formula：C₁₅H₂₀O₃

Molecular Weight：248.32

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	20554-84-1
Name	Parthenolide
Molecular Formula	C₁₅H₂₀O₃
Molecular Weight	248.32
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 692-532-0
MDL	MFCD00134592
SMILES	C/C1=C\CC[C@@](C)(O2)[C@H]2[C@@H](OC(C3=C)=O)[C@H]3CC1
InChIKey	KTEXNACQROZXEV-PVLRGYAZSA-N
InChI	InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
PubChem CID	7251185
Target Point	NF-KB
Passage	NF-κB
Background	Parthenolide is a sesquiterpene lactone. Parthenolide showed anti-inflammatory activity by inhibiting NF-κB activation. Parthenolide also specifically inhibits HDAC1 protein without affecting other Class I/II HDacs.
Biological Activity	Parthenolide 是一种 NF-κB 抑制剂，可降低组蛋白脱乙酰酶 1 (HDAC-1) 和 DNA 甲基转移酶 1。[1-3]
Data Literature Source	[1]. Nakshatri H，et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22;6:e1608. [2]. Zhao X，et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3. [3]. Barbier-Torres L，et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62(4):1237-48
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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