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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cytoskeleton > PaclitaxelCAS：33069-62-4
Molecular Formula：C47H51NO14
Molecular Weight：853.92
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 33069-62-4 |
| Name | Paclitaxel |
| Molecular Formula | C47H51NO14 |
| Molecular Weight | 853.92 |
| Solubility | Soluble in DMSO ≥8mg/mL;Soluble in Ethanol ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-285-7 |
| MDL | MFCD00869953 |
| SMILES | O=C(C1=CC=CC=C1)N[C@@H](C2=CC=CC=C2)[C@H](C(O[C@@H]3C(C)=C([C@@H](OC(C)=O)C([C@@]4(C)[C@]([C@@](CO5)(OC(C)=O)[C@@]5([H])C[C@@H]4O)([H])[C@@H]6OC(C7=CC=CC=C7)=O)=O)C(C)(C)[C@@]6(O)C3)=O)O |
| InChIKey | RCINICONZNJXQF-MZXODVADSA-N |
| InChI | InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1 |
| PubChem CID | 36314 |
| Target Point | Microtubule/Tubulin |
| Passage | Cytoskeleton |
| Background | Paclitaxel has excellent anticancer activity, which can promote microtubule assembly and prevent depolymerization, thereby stabilizing microtubules and inhibiting cancer cell mitosis, thus effectively preventing cancer cell proliferation. |
| Biological Activity | Paclitaxel是一种有效的抗癌药物的主要成分, 可以促进微管 (microtubule (MT) ) 组装, 抑制MT解聚, 并改变有丝分裂和细胞增殖所需的微管动力学[1-6]。 |
| IC50 | IC50: 4nM (MT) [1-6] |
| Data Literature Source | [1]. Park SJ， et al. Taxol induces caspase-10-dependent apoptosis. J Biol Chem. 2004 Dec 3; 279 (49) :51057-67. Epub 2004 Sep 27. [2]. Pan Z， et al. Paclitaxel attenuates Bcl-2 resistance to apoptosis in breast cancer cells through an endoplasmic reticulum-mediated calciumrelease in a dosage dependent manner. Biochem Biophys Res Commun. 2013 Feb 13. pii: S0006-291X (13) 00259-3. [3]. Cadamuro M， et al. Low dose paclitaxel reduces S100A4 nuclear import to inhibit invasion and hematogenous metastasis of cholangiocarcinoma. Cancer Res. 2016 Jun 21. [4]. Li Q， et al. Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the mouse model. FEBS J. 2016 Jun 16. [5]. Yilmaz E， et al. Sensory neuron subpopulation-specific dysregulation of intracellular calcium in a rat model of chemotherapy-induced peripheral neuropathy. Neuroscience. 2015 Aug 6; 300:210-8. [6]. Jing C， et al. Lenvatinib enhances the antitumor effects of paclitaxel in anaplastic thyroid cancer. Am J Cancer Res. 2017 Apr 1; 7 (4) :903-912. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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