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My CartCAS：1400-61-9
Molecular Formula：C47H75NO17
Molecular Weight：926.09
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Yellow to yellowish brown Solid
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| CAS | 1400-61-9 |
| Name | Nystatin |
| Molecular Formula | C47H75NO17 |
| Molecular Weight | 926.09 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Ethanol ＜1mg/mL |
| Purity | ≥98% |
| Appearance | Yellow to yellowish brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 215-749-0 |
| MDL | MFCD00036240 |
| SMILES | C[C@@H]1OC(C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@@](O)(O[C@H]2C[C@H](/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@@H]([C@@H](O)[C@H]1C)C)O[C@H]3[C@@H](O)[C@@H](N)[C@H](O)[C@@H](C)O3)C[C@H](O)[C@H]2C(O)=O)=O |
| InChIKey | VQOXZBDYSJBXMA-RKEBNKJGSA-N |
| InChI | InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1 |
| PubChem CID | 6433272 |
| Target Point | Fungal |
| Passage | Anti-infection |
| Background | Nystatin is a potent polyene antifungal antibiotic that is effective against yeast and mycoplasma. It is also a cholesterol isolator that partially prevents Oxaliplatin induced lipid raft aggregation, DR4 and DR5 aggregation, thereby reducing apoptosis. |
| Biological Activity | Nystatin是一种对酵母和支原体有效的多烯抗真菌抗生素。[1-4] |
| Data Literature Source | [1]. Ellepola AN， et al. Adhesion of oral Candida species to human buccal epithelial cells following brief exposure to nystatin. Oral Microbiol Immunol. 1999 Dec; 14 (6) :358-63. [2]. Haas M， et al. Na-K-Cl cotransport in nystatin-treated tracheal cells: regulation by isoproterenol， apical UTP， and [Cl]i. Am J Physiol. 1994 May; 266 (5 Pt 1) :C1440-52. [3]. Chen Y， et al. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011 Jun 9; 117 (23) :6392-403 [4]. Wallace TL， et al. Activity of liposomal nystatin against disseminated Aspergillus fumigatus infection in neutropenic mice. Antimicrob Agents Chemother. 1997 Oct; 41 (10) :2238-43 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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