{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > NifedipineCAS：21829-25-4
Molecular Formula：C17H18N2O6
Molecular Weight：346.33
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 21829-25-4 |
| Name | Nifedipine |
| Molecular Formula | C17H18N2O6 |
| Molecular Weight | 346.33 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-598-3 |
| MDL | MFCD00057326 |
| SMILES | O=C(C1=C(C)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2[N+]([O-])=O)OC |
| InChIKey | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 |
| PubChem CID | 4485 |
| Target Point | Calcium Channel |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is a potent calcium channel blocker. |
| Biological Activity | Nifedipine 是有效的钙离子通道 (calcium channel) 阻滞剂，常用于治疗心肌功能不全。[1-4] |
| Data Literature Source | [1]. Ratre MS，et al. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. [2]. Yu SS，et al. Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins. Front Pharmacol. 2017 Feb 13;8:60 [3]. Carvajal JA，et al. The Synergic In Vitro Tocolytic Effect of Nifedipine Plus Ritodrine on Human Myometrial Contractility. Reprod Sci. 2017 Apr;24(4):635-640. [4]. Liu P，et al. The L-type Ca(2+) Channel Blocker Nifedipine Inhibits Mycelial Growth，Sporulation，and Virulence of Phytophthora capsici. Front Microbiol. 2016 Aug 4;7:1236 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Fluoride induces neutrophil extracellular traps and aggravates brain inflammation by disrupting neutrophil calcium homeostasis and causing ferroptosis
Click to check >>Author：Dongxu Wang, Kai Yin, Yue Zhang, Hongmin Lu, Lulu Hou, Hongjing Zhao, Mingwei Xing
IF：9.9880
Publish_to：ENVIRONMENTAL POLLUTION
PMID：37209896
Costunolide covalently targets and inhibits CaMKII phosphorylation to reduce ischemia-associated brain damage
Click to check >>Author：Wenjuan Liu, Wei Yang, Ruixue Niu, Longfei Cong, Min Jiang, Gang Bai
IF：6.6560
Publish_to：PHYTOMEDICINE
PMID：37087789
Manual Download
