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My CartCAS：1405-10-3
Molecular Formula：C23H52N6O25S3
Molecular Weight：908.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1405-10-3 |
| Name | Neomycin Sulfate |
| Molecular Formula | C23H52N6O25S3 |
| Molecular Weight | 908.88 |
| Solubility | Soluble in Water ≥50mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 215-773-1 |
| MDL | MFCD00037007 |
| SMILES | O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4] |
| InChIKey | OIXVKQDWLFHVGR-WQDIDPJDSA-N |
| InChI | InChI=1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 |
| PubChem CID | 197162 |
| Target Point | Bacterial;Phospholipase C (PLC) |
| Passage | Metabolic Enzyme&Protease; Anti-infection |
| Background | It is an aminoglycoside antibiotic that exerts antibacterial activity through irreversible binding of nuclear 30S ribosomal subunits， thereby blocking the synthesis of bacterial proteins， and is often used to screen prokaryotic and eukaryotic cells with Neo resistance genes. |
| Biological Activity | Neomycin sulfate是用于预防或治疗 细菌 感染的氨基糖苷类抗生素。[1-4] |
| Data Literature Source | [1]. Carney，D.H.，et al. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Cell，1985. 42(2): p. 479-88. [2]. Nakashima，S.，et al. Neomycin is a potent agent for arachidonic acid release in human platelets. Biochem Biophys Res Commun，1987. 146(2): p. 820-6. [3]. Liscovitch，M.，et al.，Inhibition of neural phospholipase D activity by aminoglycoside antibiotics. Biochem J，1991. 279 ( Pt 1): p. 319-21. [4]. Huang K，et al. CRAC channel is inhibited by neomycin in a Ptdlns(4，5)P2-independent manner. Cell Biochem Funct. 2015 Mar;33(2):97-100 |
| Unit | Bottle |
| Specification | 200mg 10mM*1mL in Water 500mg 1g 5g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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