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Mangiferin

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Cat.No：IM0030 Solarbio

CAS：4773-96-0

Molecular Formula：C₁₉H₁₈O₁₁

Molecular Weight：422.34

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	4773-96-0
Name	Mangiferin
Molecular Formula	C₁₉H₁₈O₁₁
Molecular Weight	422.34
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 624-757-7
MDL	MFCD00075656
SMILES	O[C@@H]([C@H](O)[C@@H](CO)O1)[C@@H](O)[C@@H]1C2=C(O)C3=C(C=C2O)OC4=CC(O)=C(O)C=C4C3=O
InChIKey	AEDDIBAIWPIIBD-ZJKJAXBQSA-N
InChI	InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19+/m1/s1
PubChem CID	5281647
Target Point	Nrf2;p65
Passage	NF-κB
Background	Mangiferin is an Nrf2 activator. Mangiferin inhibits nuclear translocation of NF-κB subunits p65 and p50.
Biological Activity	Mangiferin 是一种 Nrf2 激活剂。Mangiferin 抑制 NF-κB 亚基 p65 和 p50 的核移位。[1-2]
Data Literature Source	[1]. Zhang BP，et al. Mangiferin activates Nrf2-antioxidant response element signaling without reducing the sensitivity to etoposide of human myeloid leukemia cells in vitro. Acta Pharmacol Sin. 2014 Feb;35(2):257-66. [2]. Dilshara MG，et al. Mangiferin inhibits tumor necrosis factor-α-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-κB activity. BMB Rep. 2015 Oct;48(10):559-64
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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