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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > LuteolinCAS：491-70-3
Molecular Formula：C15H10O6
Molecular Weight：286.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 491-70-3 |
| Name | Luteolin |
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.24 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-741-0 |
| MDL | MFCD00017309 |
| SMILES | O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13 |
| InChIKey | IQPNAANSBPBGFQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H |
| PubChem CID | 5280445 |
| Target Point | PDE;Nrf2 |
| Passage | Metabolic Enzyme&Protease；NF-κB |
| Background | Luteolin, a flavonoid, is a potent Nrf2 inhibitor and a non-selective PDE inhibitor with anti-inflammatory and anticancer activity. |
| Biological Activity | Luteolin is a potent PDE and Nrf2 inhibitor.Luteolin can protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in addition to an antioxidant effect.[1-3] |
| Data Literature Source | [1]. Yu MC，Chen JH，Lai CY，Han CY，Ko WC. Luteolin，a non-selective competitive inhibitor of phosphodiesterases 1-5，displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010 Feb 10;627(1-3):269-75. [2].Abu-Elsaad N，El-Karef A. Protection against nonalcoholic steatohepatitis through targeting IL-18 and IL-1alpha by luteolin. Pharmacol Rep. 2019 Aug;71(4):688-694. [3].Tang X，Wang H，Fan L，Wu X，Xin A，Ren H，Wang XJ. Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs. Free Radic Biol Med. 2011 Jun 1;50(11):1599-609. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Xu X, et al. Biochem Biophys Res Commun. 2023 Jun 18;661:108-118.
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Rhizobial HmuSpSym as a heme-binding factor is required for optimal symbiosis between Mesorhizobium amorphae CCNWGS0123 and Robinia pseudoacacia
Click to check >>Author：Huo H. Zong L. Liu Y. Chen W. Chen J. Wei G
IF：6.5500
Publish_to：Plant Cell Environ
PMID：35419804
Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study
Click to check >>Author：Lei Chen，Tong Yu，Yiman Zhai，Hongguang Nie，Xin Li，Y
IF：5.6000
Publish_to：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
PMID：37373270
In Vitro Effect of Flavonoids on Basophils Degranulation and Intestinal Epithelial Barrier Damage Induced by ω-5 Gliadin-Derived Peptide
Click to check >>Author：Wu S; Zhang R; Liu Y; Gao J; Wu Y; Tu C; Chen H; Y
IF：5.2000
Publish_to：Foods
PMID：36496664
Luteolin attenuates lipopolysaccharide-induced acute lung injury/acute respiratory distress syndrome by activating alveolar epithelial sodium channels via cGMP/PI3K pathway
Click to check >>Author：候亚鹏 聂宏光
IF：4.3600
Publish_to：Journal of Ethnopharmacology
PMID：34841064
A Nod factor- and type III secretion system-dependent manner for Robinia pseudoacacia to establish symbiosis with Mesorhizobium amorphae CCNWGS0123.
Click to check >>Author：Huo H, Wang X, Liu Y, Chen J, Wei G.
IF：3.6170
Publish_to：Tree Physiol.
PMID：33219377
Experimental study on the effect of luteolin on the proliferation;apoptosis and expression of inflammation-related mediators in lipopolysaccharide-induced keratinocytes
Click to check >>Author：Xinpei Wang;Yue Yao;Yexian Li;Shujing Guo;Yanjia Li;Guoqiang Zhang
IF：3.5000
Publish_to：Int J Immunopathol Pharmacol
PMID：37024790
Experimental study on the effect of luteolin on the proliferation,apoptosis and expression of inflammation-related mediators in lipopolysaccharide-induced keratinocytes
Click to check >>Author：Xinpei Wang, Yue Yao, Yexian Li, Shujing Guo, Yanjia Li, Guoqiang Zhang
IF：3.2980
Publish_to：INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
PMID：37024790
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