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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > α-Lipoic AcidCAS：1077-28-7
Molecular Formula：C8H14O2S2
Molecular Weight：206.33
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1077-28-7 |
| Name | α-Lipoic Acid |
| Molecular Formula | C8H14O2S2 |
| Molecular Weight | 206.33 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 214-071-2 |
| MDL | MFCD00005474 |
| SMILES | O=C(O)CCCCC1SSCC1 |
| InChIKey | AGBQKNBQESQNJD-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10) |
| PubChem CID | 864 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | It is an antioxidant and an important cofactor for mitochondrial enzyme complexes. Inhibits NF-κB-dependent activation of HIV-1 LTR. |
| Biological Activity | α-Lipoic Acid 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。α-Lipoic Acid 可抑制 NF-κB 依赖性的 HIV-1 LTR活化。[1-3] |
| Data Literature Source | [1]. Xiao L，et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. [2]. Yang Y，et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1，FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217. [3]. Lei D，et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Yang Y, et al. Mediators Inflamm. 2022 Jun 7;2022:1894379.
Yang Y, et al. Mediators Inflamm. 2022 Jun 7;2022:1894379.
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