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My CartCAS：103476-89-7
Molecular Formula：C20H38N6O4·1/2H2SO4
Molecular Weight：475.59
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 103476-89-7 |
| Name | Leupeptin |
| Molecular Formula | C20H38N6O4·1/2H2SO4 |
| Molecular Weight | 475.59 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 600-443-5 |
| MDL | MFCD00037012 |
| SMILES | O=C[C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(N)=N.[0.5H2SO4] |
| InChIKey | CIPMKIHUGVGQTG-VFFZMTJFSA-N |
| InChI | InChI=1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1 |
| PubChem CID | 2733491 |
| Target Point | Cathepsin;Serine Protease |
| Passage | Metabolic Enzyme/Protease |
| Background | Leupeptin， a broad-spectrum covalent inhibitor of serine， cysteine， and threonine proteases， showed inhibitory activity against Mpro， with a 50% inhibitory concentration (IC50) value of 127.2 μM in vitro in our study here. Leupeptin can also inhibit SARS-CoV-2 in Vero cells， with 50% effective concentration (EC50) values of 42.34 μM.[1] |
| Unit | Bottle |
| Specification | 1mg 10mM*1mL in DMSO 10mM*1mL in Water 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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