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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > KetoprofenCAS：22071-15-4
Molecular Formula：C16H14O3
Molecular Weight：254.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 22071-15-4 |
| Name | Ketoprofen |
| Molecular Formula | C16H14O3 |
| Molecular Weight | 254.28 |
| Solubility | Soluble in DMSO ≥20mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-759-8 |
| MDL | MFCD00055790 |
| SMILES | O=C(C1=CC=CC=C1)C2=CC=CC(C(C(O)=O)C)=C2 |
| InChIKey | DKYWVDODHFEZIM-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) |
| PubChem CID | 3825 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | It is a non-steroidal anti-inflammatory agent that can effectively inhibit the activity of COX. |
| Biological Activity | Ketoprofen 是一种非甾体抗炎剂，能够有效地抑制 COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的 IC50 值分别为 2 nM 和 26 nM。[1-2] |
| Data Literature Source | [1]. Palomer A，et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [2]. Negus SS，et al. Effects of ketoprofen，morphine，and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion
Click to check >>Author：Li M; Meng N; Guo X; Niu X; Zhao Z; Wang W; Xie X;
IF：4.8000
Publish_to：Front Aging Neurosci
PMID：32581761
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