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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > KaempferolCAS：520-18-3
Molecular Formula：C15H10O6
Molecular Weight：286.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 520-18-3 |
| Name | Kaempferol |
| Molecular Formula | C15H10O6 |
| Molecular Weight | 286.24 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-287-6 |
| MDL | MFCD00016938 |
| SMILES | OC1=C2C(OC(C3=CC=C(O)C=C3)=C(O)C2=O)=CC(O)=C1 |
| InChIKey | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H |
| PubChem CID | 5280863 |
| Target Point | Estrogen Receptor |
| Passage | Endocrinology & Hormones |
| Background | Kaempferol is a flavonoid that is an inverse agonist of ERRα and ERRγ. Inhibits topoisomerase I-catalyzed DNA religation and fatty acid synthase activity. |
| Biological Activity | Kaempferol 在乳腺癌细胞中抑制雌激素受体 (estrogen receptor α) 表达，在胶质母细胞瘤细胞和肺癌细胞中，通过激活 MEK-MAPK 诱导细胞凋亡。[1-4] |
| Data Literature Source | [1]. Luo H，et al. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine. 2012; 7: 3951-3959. [2]. Luo H，et al. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 September 15; 128(2): 513-519. [3]. An M，et al. Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48(4):235-43. [4]. Shin D，et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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Characterization of the Synergistic Antioxidant Activity of Epigallocatechin Gallate (EGCG) and Kaempferol
Click to check >>Author：Qiang Zhang, Junkun Pan, Hui Liu, Zhonggao Jiao
IF：4.6000
Publish_to：MOLECULES
PMID：37446925
Profiling of phenolic acids and flavonoids in sweet potato (Ipomoea batatas L.) leaves and evaluation of their anti-oxidant and hypoglycemic activities
Click to check >>Author：D Luo; Mu T ; Sun H .
IF：4.3050
Publish_to：[J]. Food Bioscience
PMID：
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