{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > IcariinCAS：489-32-7
Molecular Formula：C33H40O15
Molecular Weight：676.65
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 489-32-7 |
| Name | Icariin |
| Molecular Formula | C33H40O15 |
| Molecular Weight | 676.65 |
| Solubility | Soluble in DMSO ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 610-440-0 |
| MDL | MFCD00210516 |
| SMILES | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(C/C=C(C)/C)C(OC(C3=CC=C(OC)C=C3)=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)C5=O)=C5C(O)=C2)[C@@H]1O |
| InChIKey | TZJALUIVHRYQQB-XLRXWWTNSA-N |
| InChI | InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1 |
| PubChem CID | 5318997 |
| Target Point | Phosphodiesterase (PDE);PPAR |
| Passage | Metabolic Enzyme&Protease;Cell Cycle;DNA Damage/DNA Repair |
| Background | Icariin is a flavonoid glycoside that inhibits PDE5 and PDE4 activity. It is also a PPARα activator. |
| Biological Activity | Icariin 是一种黄酮醇苷。 Icariin 抑制 PDE5 和 PDE4 活性, IC50 分别为 432 nM 和 73.50 μM。Icariin 也是一种 PPARα 激活剂[1-4]。 |
| IC50 | PDE5:432nM (IC50) PDE4:73.5μM (IC50) [1-4] |
| Data Literature Source | [1]. Xin ZC， et al. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar; 5 (1) :15-8. [2]. Lu YF， et al. Icariin is a PPARα activator inducing lipid metabolic gene expression in mice. Molecules. 2014 Nov 6; 19 (11) :18179-91. [3]. Hu Y， et al. Effects and mechanisms of icariin on atherosclerosis. Int J Clin Exp Med. 2015 Mar 15; 8 (3) :3585-9. [4]. Chen M， et al. Effects of icariin on reproductive functions in male rats. Molecules. 2014 Jul 3; 19 (7) :9502-14. |
| Unit | Bottle |
| Specification | 20mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Li T, et al. Exp Ther Med. 2021 Oct;22(4):1070.
Sorry, there is no more information.
Icariin alleviates ferroptosis-related atherosclerosis by promoting autophagy in xo-LDL-induced vascular endothelial cell injury and atherosclerotic mice
Click to check >>Author：Xindong Wang, Meng Zhang, Chenhan Mao, Chengbo Zhang, Wenqi Ma, Jiahui Tang, Dongyang Xiang, Xiaoxia Qi
IF：7.2000
Publish_to：PHYTOTHERAPY RESEARCH
PMID：37344941
Synthesis of icariin in tobacco leaf by overexpression of a glucosyltransferase gene from Epimedium sagittatum
Click to check >>Author：Yang X .Chen J .Huang W
IF：5.6180
Publish_to：Industrial Crops and Products
PMID：
Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
Click to check >>Author：Wang Lifeng, Peng Guanfa, Chen Li, Guo Mingling, Wang Bingyu, Zhang Yunmeng, Zhou Jianshun, Zhong Maolin, Ye Junming
IF：3.0000
Publish_to：Frontiers in Behavioral Neuroscience
PMID：37351155
A steroid-induced osteonecrosis model established using an organ-on-a-chip platform
Click to check >>Author：Li T; Liu Y; Zhang Q; Sun W; Dong Y
IF：2.7000
Publish_to：Exp Ther Med
PMID：34447463
Manual Download
