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My CartCAS：31282-04-9
Molecular Formula：C20H37N3O13
Molecular Weight：527.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥90%
Appearance：Off-white to yellow Solid
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| CAS | 31282-04-9 |
| Name | Hygromycin B |
| Molecular Formula | C20H37N3O13 |
| Molecular Weight | 527.52 |
| Solubility | Soluble in Water ≥100mg/mL |
| Purity | ≥90% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 250-545-5 |
| MDL | MFCD00036846 |
| SMILES | O[C@H]([C@H]1O)C2(O[C@@]([C@@H](N)CO)([H])[C@@H]1O)O[C@@]([C@@H](O[C@@H]3CO)O[C@@]([C@H]([C@H](N)C4)O)([H])[C@@H]([C@H]4NC)O)([H])[C@@]([C@H]3O)([H])O2 |
| InChIKey | GRRNUXAQVGOGFE-XKIAHZFYSA-N |
| InChI | InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1 |
| PubChem CID | 23777801 |
| Target Point | Bacterial;Fungal |
| Passage | Anti-infection |
| Background | It is an aminoglycoside antibiotic that inhibits prokaryotic and eukaryotic cells, inhibiting protein synthesis by interfering with translocation and promoting mistranslation of 70S ribosomes. |
| Biological Activity | Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.[1-3] |
| Data Literature Source | [1]. Pardo JM，et al. Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus--the producing organism. J Gen Microbiol. 1985 Jun;131(6):1289-98. [2]. González A，et al. Studies on the mode of action of hygromycin B，an inhibitor of translocation in eukaryotes. Biochim Biophys Acta. 1978 Dec 21;521(2):459-69. [3]. Pfister P，et al. Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B. Antimicrob Agents Chemother. 2003 May;47(5):1496-502. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in Water 200mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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