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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > HomoharringtonineCAS：26833-87-4
Molecular Formula：C29H39NO9
Molecular Weight：545.62
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 26833-87-4 |
| Name | Homoharringtonine |
| Molecular Formula | C29H39NO9 |
| Molecular Weight | 545.62 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD03410264 |
| SMILES | [H][C@@]12[C@](CCC3)(C=C(OC)[C@]2(OC([C@](CCCC(O)(C)C)(O)CC(OC)=O)=O)[H])N3CCC4=CC5=C(OCO5)C=C14 |
| InChIKey | HYFHYPWGAURHIV-JFIAXGOJSA-N |
| InChI | InChI=1S/C29H39NO9/c1-27(2,33)8-5-10-29(34,16-23(31)36-4)26(32)39-25-22(35-3)15-28-9-6-11-30(28)12-7-18-13-20-21(38-17-37-20)14-19(18)24(25)28/h13-15,24-25,33-34H,5-12,16-17H2,1-4H3/t24-,25-,28+,29-/m1/s1 |
| PubChem CID | 285033 |
| Target Point | Others |
| Passage | Others |
| Background | Homoharringtonine is an alkaloid with anti-tumor properties that inhibits protein translation by preventing the initial extension step of protein synthesis through its interaction with the ribosome A site. Homoharringtonine reversibly inhibits IL-6-induced phosphorylation of STAT3 Tyrosine 705 and decreases anti-apoptotic protein expression. |
| Biological Activity | Homoharringtonine (Omacetaxine mepesuccinate;HHT) 是具有抗肿瘤特性的细胞毒性生物碱，其通过抑制翻译延长来起作用。[1] |
| Data Literature Source | [1]. Cao W，et al. Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells. Sci Rep. 2015 Jul 13;5:8477 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Determination of berberine-upregulated endogenous short-chain fatty acids through derivatization by 2-bromoacetophenone.
Click to check >>Author：Ma SR; Tong Q; Zhao ZX; Cong L; Yu JB; Fu J; Han P
IF：3.7400
Publish_to：Anal Bioanal Chem.
PMID：30972469
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