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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > GlibenclamideCAS：10238-21-8
Molecular Formula：C23H28ClN3O5S
Molecular Weight：494
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 10238-21-8 |
| Name | Glibenclamide |
| Molecular Formula | C23H28ClN3O5S |
| Molecular Weight | 494 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 233-570-6 |
| MDL | MFCD00056625 |
| SMILES | ClC1=CC(C(NCCC2=CC=C(S(NC(NC3CCCCC3)=O)(=O)=O)C=C2)=O)=C(OC)C=C1 |
| InChIKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) |
| PubChem CID | 3488 |
| Target Point | Potassium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is a sulfonylurea compound that regulates insulin production. It is also a selective, ATP-sensitive inhibitor of potassium channels. |
| Data Literature Source | [1]. Qiu Y，et al. Glyburide Regulates UCP1 Expression in Adipocytes Independent of KATP Channel Blockade. iScience. 2020;23(9):101446. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Liu H, et al. Biochem Pharmacol. 2020 Jul;177113998.
Liu H, et al. Biochem Pharmacol. 2020 Jul;177113998.
Liu H, et al. Biochem Pharmacol. 2020 Jul;177113998.
Sorry, there is no more information.
NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury
Click to check >>Author：Liu H. Gu C. Liu M. Liu G. Wang Y
IF：5.2860
Publish_to：Biochem Pharmacol
PMID：32353421
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