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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Ginsenoside Rg3CAS：14197-60-5
Molecular Formula：C42H72O13
Molecular Weight：785.02
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 14197-60-5 |
| Name | Ginsenoside Rg3 |
| Molecular Formula | C42H72O13 |
| Molecular Weight | 785.02 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD06410950 |
| SMILES | C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)C)(CC[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](C)(O)CC/C=C(C)/C)([H])CC6)C |
| InChIKey | RWXIFXNRCLMQCD-JBVRGBGGSA-N |
| InChI | InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1 |
| PubChem CID | 9918693 |
| Target Point | Sodium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | Ginsenoside Rg3 inhibits Na+ and hKv1.4 channels. Ginsenoside Rg3 also inhibits Aβ, NF-κB activity and COX-2 expression. |
| Biological Activity | Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+ 和 hKv1.4 通道，IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 Aβ，NF-κB 活性和 COX-2 表达。[1-4] |
| Data Literature Source | [1]. Kim JH，et al. A role for the carbohydrate portion of ginsenoside Rg3 in Na+ channel inhibition. Mol Cells. 2005 Feb 28;19(1):137-42. [2]. Lee JH，et al. Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. Mol Pharmacol. 2008 Mar;73(3):619-26. [3]. Lee IS，et al. Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue. J Immunol Res. 2016;2016:7521601. [4]. Kang MS，et al. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. J Biol Chem. 2013 Jul 19;288(29):20868-82. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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