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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Ginsenoside RdCAS：52705-93-8
Molecular Formula：C48H82O18
Molecular Weight：947.15
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 52705-93-8 |
| Name | Ginsenoside Rd |
| Molecular Formula | C48H82O18 |
| Molecular Weight | 947.15 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 258-118-5 |
| MDL | MFCD00210508 |
| SMILES | C[C@](CC/C=C(C)/C)([C@]1([H])[C@]([C@H](O)C[C@@]2([H])[C@@]3(C)CC[C@]4([H])[C@]2(C)CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C4(C)C)([H])[C@@]3(C)CC1)O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O |
| InChIKey | RLDVZILFNVRJTL-IWFVLDDISA-N |
| InChI | InChI=1S/C48H82O18/c1-22(2)10-9-14-48(8，66-42-39(60)36(57)33(54)26(20-50)62-42)23-11-16-47(7)31(23)24(52)18-29-45(5)15-13-30(44(3，4)28(45)12-17-46(29，47)6)64-43-40(37(58)34(55)27(21-51)63-43)65-41-38(59)35(56)32(53)25(19-49)61-41/h10，23-43，49-60H，9，11-21H2，1-8H3/t23-，24+，25+，26+，27+，28-，29+，30-，31-，32+，33+，34+，35-，36-，37-，38+，39+，40+，41-，42-，43-，45-，46+，47+，48-/m0/s1 |
| PubChem CID | 11679800 |
| Target Point | NF-kB;COX-2;iNOS |
| Passage | NF-κB;Immunology & Inflammation |
| Background | It inhibits TNFα-induced NF-κB transcriptional activity. Inhibits COX-2 and iNOS mRNA expression and also inhibits Ca2+ influx. |
| Biological Activity | Ginsenoside Rd 抑制 TNFα 诱导的 NF-κB 转录活性，IC50 为 12.05±0.82 μM。Ginsenoside Rd 抑制 COX-2 和 iNOS mRNA 的表达。Ginsenoside Rd 还抑制 Ca2+ 内流。Ginsenoside Rd 抑制CYP2D6，CYP1A2，CYP3A4 和 CYP2C9，IC50 分别为 58.0±4.5 μM，78.4±5.3 μM，81.7±2.6 μM 和 85.1±9.1 μM。[1-4] |
| Data Literature Source | [1]. Song SB，et al. Inhibition of TNF-α-mediated NF-κB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves. J Ginseng Res. 2012 Apr;36(2):146-52. [2]. Lu C，et al. Inhibition of L-type Ca2+ current by ginsenoside Rd in rat ventricular myocytes. J Ginseng Res. 2015 Apr;39(2):169-77. [3]. Huang G，et al. Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice. Sci Rep. 2017 Oct 2;7(1):12552. [4]. Liu Y，et al. Ginsenoside metabolites，rather than naturally occurring ginsenosides，lead to inhibition of human cytochrome P450 enzymes. Toxicol Sci. 2006 Jun;91(2):356-64. |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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