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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Ginsenoside Rb3CAS：68406-26-8
Molecular Formula：C53H90O22
Molecular Weight：1079.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 68406-26-8 |
| Name | Ginsenoside Rb3 |
| Molecular Formula | C53H90O22 |
| Molecular Weight | 1079.28 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD10566396 |
| SMILES | C[C@]([C@@](C[C@H]1O)([H])[C@]2(CC[C@@H]3O[C@@](O[C@H](CO)[C@@H](O)[C@@H]4O)([H])[C@@H]4O[C@]([C@@H]([C@@H](O)[C@@H]5O)O)([H])O[C@@H]5CO)C)(CC[C@@]2([H])C3(C)C)[C@]6([C@@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO[C@H](OC[C@@H](O)[C@@H]8O)[C@@H]8O)([H])CC6)C |
| Target Point | NF-kB;COX-2;iNOS |
| Passage | NF-κB;Immunology & Inflammation |
| Background | Ginsenoside Rb3 has been reported to inhibit TNFα-induced NF-κB transcriptional activity in 293T cell line with IC50 of 8.2 μM. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA. |
| Biological Activity | Ginsenoside Rb3 是从 Panax notoginseng 中提取的。在 293T 细胞系中 Ginsenoside Rb3 抑制 TNFα 诱导的 NF-κB 转录活性，IC50 为 8.2 μM。Ginsenoside Rb3 还抑制 COX-2 和 iNOS mRNA的诱导。[1-3] |
| Data Literature Source | [1]. He F，et al. Antitumor effects of dammarane-type saponins from steamed Notoginseng. Pharmacogn Mag. 2014 Jul;10(39):314-7. [2]. Zhu JR，et al. Protective effects of ginsenoside Rb(3) on oxygen and glucose deprivation-induced ischemic injury in PC12 cells. Acta Pharmacol Sin. 2010 Mar;31(3):273-80. [3]. Huang G，et al. Ginsenosides Rb3 and Rd reduce polyps formation while reinstate the dysbiotic gut microbiota and the intestinal microenvironment in ApcMin/+ mice. Sci Rep. 2017 Oct 2;7(1):12552 |
| Unit | Bottle |
| Specification | 5mg 10mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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