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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Ginsenoside Rb1CAS：41753-43-9
Molecular Formula：C54H92O23
Molecular Weight：1109.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 41753-43-9 |
| Name | Ginsenoside Rb1 |
| Molecular Formula | C54H92O23 |
| Molecular Weight | 1109.29 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 255-532-8 |
| MDL | MFCD00133367 |
| SMILES | C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO)([H])CC2)([H])[C@]3(CC[C@@H]4O[C@@](O[C@H](CO)[C@@H](O)[C@@H]7O)([H])[C@@H]7O[C@]([C@@H]([C@@H](O)[C@@H]8O)O)([H])O[C@@H]8CO)C |
| InChIKey | GZYPWOGIYAIIPV-JBDTYSNRSA-N |
| InChI | InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1 |
| PubChem CID | 9898279 |
| Target Point | TLR3, TLR4（Toll-like Receptor）;IRAK-1;Na+/K+ ATPase;TNF-α;p65;iNOS |
| Passage | Apoptosis;NF-κB;Immunology & Inflammation;Membrane Transporter&Ion Channel |
| Background | Ginsenoside Rb1 inhibited Na+, K+-ATPase activity. It also inhibited IRAK-1 activation and phosphorylation of NF-κB p65. |
| Biological Activity | Ginsenoside Rb1 是中药 Panax ginseng 的成分。Ginsenoside 抑制 Na+, K+-ATPase 活性，IC50 为 6.3±1.0 μM。Ginsenoside Rb1 也抑制 IRAK-1 激活及 NF-κB p65 的磷酸化。[1-5] |
| Data Literature Source | [1]. Cao J，et al. Inhibitory effects of ginsenoside Rg1 and Rb1 on rat brain microsomal Na+，K+-ATPase activity. Zhongguo Yao Li Xue Bao. 1990 Jan;11(1):10-4. [2]. Joh EH，et al. Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation. Biochem Pharmacol. 2011 Aug 1;82(3):278-86. [3]. Zhang J，et al. Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis. Drug Metab Dispos. 2015 Aug;43(8):1181-9. [4]. Jiang Y，et al. Ginsenoside Rb1 Treatment Attenuates Pulmonary Inflammatory Cytokine Release and Tissue Injury following Intestinal Ischemia Reperfusion Injury in Mice. Oxid Med Cell Longev. 2015;2015:843721. [5]. Zhang Y，et al. Ginsenoside Rb1 ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules by intervening in both trans- and paracellular pathway. Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G289-300. |
| Unit | Bottle |
| Specification | 10mg 20mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Zhang H, et al. Life Sci. 2019 Jul 15;229:210-218.
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