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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > GenisteinCAS：446-72-0
Molecular Formula：C15H10O5
Molecular Weight：270.24
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 446-72-0 |
| Name | Genistein |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.24 |
| Solubility | Soluble in DMSO ≥50mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-174-9 |
| MDL | MFCD00016952 |
| SMILES | OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1 |
| InChIKey | TZBJGXHYKVUXJN-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H |
| PubChem CID | 5280961 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | Genistein is a soy isoflavone and a multiplex tyrosine kinase inhibitor. Genistein has the activity of inducing programmed cell death, altering the cell cycle and angiogenesis, and inhibiting metastasis, and can be used for the research of cancer chemopreventive agents. |
| Biological Activity | Genistein是一种大豆异黄酮，是一种多重的酪氨酸激酶 (tyrosine kinases) 抑制剂，是对多种癌症的化疗剂，主要通过改变细胞凋亡，细胞周期和血管生成以及抑制转移。[1-3] |
| IC50 | EGFR:0.6μM(Cell Assay) |
| Data Literature Source | [1]. Peterson G，et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7(10):1345-51. [2]. Jalili C，et al. Effect of Genistein on reproductive parameter and serum nitric oxide levels in morphine-treated mice. Int J Reprod Biomed (Yazd). 2016 Feb;14(2):95-102. [3]. Ding S，et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11(5):e0155352 |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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