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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GemcitabineCAS：95058-81-4
Molecular Formula：C9H11F2N3O4
Molecular Weight：263.2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 95058-81-4 |
| Name | Gemcitabine |
| Molecular Formula | C9H11F2N3O4 |
| Molecular Weight | 263.2 |
| Solubility | Soluble in Water/DMSO ≥3mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 619-100-6 |
| MDL | MFCD00869720 |
| SMILES | O=C1N(C=CC(N)=N1)[C@H]2C(F)([C@@H]([C@H](O2)CO)O)F |
| InChIKey | SDUQYLNIPVEERB-QPPQHZFASA-N |
| InChI | InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1 |
| PubChem CID | 60750 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | Gemcitabine is a DNA synthesis inhibitor. Is a pyrimidine nucleoside analog. It can inhibit DNA synthesis and repair, leading to autophagy and apoptosis. |
| Biological Activity | Gemcitabine (NSC 613327;LY188011) 是一种 DNA合成 抑制剂，抑制 BxPC-3，Mia Paca-2，PANC-1，PL-45 和 AsPC-1细胞生长的 IC50 分别为 37.6, 42.9, 92.7, 89.3 和 131.4 nM[1-5]。 |
| Data Literature Source | [1]. Wang H，et al. Enhanced efficacy of Gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrativenucleoside transporter 1. Anticancer Res. 2011 Oct;31(10):3171-80. [2]. Yip-Schneider MT，et al. Dimethylaminoparthenolide and Gemcitabine: a survival study using a genetically engineered mouse model of pancreatic cancer. BMC Cancer. 2013 Apr 17;13:194. [3]. Gagnadoux F，et al. Safety of pulmonary administration of gemcitabine in rats. J Aerosol Med. 2005 Summer;18(2):198-206 [4]. Lou M，et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292(22):9136-9149. [5]. Wang Y，et al. Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways. Chem Biol Interact. 2018 May 18;290:44-51. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Pan Y, et al. Microsyst Nanoeng. 2020 Mar 9;6:23.
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3D microgroove electrical impedance sensing to examine 3D cell cultures for antineoplastic drug assessment
Click to check >>Author：Pan Y;Jiang D;Gu C;Qiu Y;Wan H;Wang P.
IF：5.6160
Publish_to：Microsyst Nanoeng
PMID：34567638
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