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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > GefitinibCAS：184475-35-2
Molecular Formula：C22H24ClFN4O3
Molecular Weight：446.9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 184475-35-2 |
| Name | Gefitinib |
| Molecular Formula | C22H24ClFN4O3 |
| Molecular Weight | 446.9 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 643-034-7 |
| MDL | MFCD04307832 |
| SMILES | ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F |
| InChIKey | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
| PubChem CID | 123631 |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | It is an effective and selective EGFR tyrosine kinase inhibitor and can also induce autophagy. It has anti-tumor activity. |
| Biological Activity | Gefitinib 是一种有效的表皮生长因子受体 (EGFR) 抑制剂，在 NR6wtEGFR 细胞中 IC50 值为 2-37 nM。[1-6] |
| Data Literature Source | [1]. Pedersen MW，et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. [2]. Moasser MM，et al. The tyrosine kinase inhibitor ZD1839 ('Iressa') inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8. [3]. Morgillo F，et al. Synergistic effects of metformin treatment in combination with gefitinib，a selective EGFR tyrosine kinase inhibitor，in LKB1 wild-type NSCLC cell lines. Clin Cancer Res. 2013 Jul 1;19(13):3508-19. [4]. Miyake K，et al. Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis，but attenuates lung fibrosis in response to radiation injury in rats. J Med Invest. 2012;59(1-2):174-85. [5]. Noh CK，et al. Simultaneous quantification of volitinib and gefitinib in rat plasma by HPLC-MS/MS for application to a pharmacokinetic study in rats. J Sep Sci. 2017 Jul 27. [6]. Dhar D，et al. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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