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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > GalanthamineCAS：357-70-0
Molecular Formula：C17H21NO3
Molecular Weight：287.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 357-70-0 |
| Name | Galanthamine |
| Molecular Formula | C17H21NO3 |
| Molecular Weight | 287.35 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 609-175-3 |
| MDL | MFCD00867189 |
| SMILES | O[C@@H]1C[C@@H]2OC3=C4C(CN(C)CC[C@]42C=C1)=CC=C3OC |
| InChIKey | ASUTZQLVASHGKV-JDFRZJQESA-N |
| InChI | InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1 |
| PubChem CID | 9651 |
| Target Point | AChE |
| Passage | Neuronal Signaling |
| Background | Galanthamine is a potent acetylcholinesterase (AChE) inhibitor. |
| Biological Activity | Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂，IC50 为 500 nM。[1-3] |
| IC50 | 0.5μM(AChE)[1] |
| Data Literature Source | [1]. Melanie-Jayne R. Howes，et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(SI 1):67-86. [2]. Kuryatov A，et al. Roles of accessory subunits in alpha4beta2(*) nicotinic receptors. Mol Pharmacol. 2008 Jul;74(1):132-43. [3]. Kita Y，et al. Galantamine increases hippocampal insulin-like growth factor 2 expression via α7 nicotinic acetylcholine receptors in mice. Psychopharmacology (Berl). 2013 Feb;225(3):543-51. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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