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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > 5-FluorouracilCAS：51-21-8
Molecular Formula：C4H3FN2O2
Molecular Weight：130.08
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 51-21-8 |
| Name | 5-Fluorouracil |
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.08 |
| Solubility | Soluble in DMSO ≥4mg/mL;Soluble in Water ≥5mg/mL(Need ultrasonic or Water bath) |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-085-6 |
| MDL | MFCD00006018 |
| SMILES | O=C(N1)NC=C(F)C1=O |
| InChIKey | GHASVSINZRGABV-UHFFFAOYSA-N |
| InChI | InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
| PubChem CID | 3385 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | 5-Fluorouracil has antitumor activity. It is an analog of uracil (nucleoside antimetabolite/analog), which can affect pyrimidine synthesis by inhibiting thymidylate synthase. |
| Biological Activity | 5-Fluorouracil 是一种有效的抗肿瘤剂，通过抑制胸苷酸合成酶从而消耗细胞内dTTP来影响嘧啶合成。[1-4] |
| Data Literature Source | [1]. Han R， et al. Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy. J Drug Target. 2016 Jun 29:1-28. [Epub ahead of print] [2]. McQuade RM， et al. Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil. Neurogastroenterol Motil. 2016 Jun 28. [3]. Zeng Q， et al. Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells. Mol Cell Biochem. 2016 Jul; 418 (1-2) :137-46. [4]. Yin L， et al. Antitumor effects of oncolytic herpes simplex virus type 2 against colorectal cancer in vitro and in vivo. Ther Clin Risk Manag. 2017 Feb 7; 13:117-130. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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