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Flumequine

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Cat.No：IF0140 Solarbio

CAS：42835-25-6

Molecular Formula：C₁₄H₁₂FNO₃

Molecular Weight：261.25

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	42835-25-6
Name	Flumequine
Molecular Formula	C₁₄H₁₂FNO₃
Molecular Weight	261.25
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 255-962-6
MDL	MFCD00079298
SMILES	O=C(C1=CN2C(C)CCC3=C2C(C1=O)=CC(F)=C3)O
InChIKey	DPSPPJIUMHPXMA-UHFFFAOYSA-N
InChI	InChI=1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)
PubChem CID	3374
Target Point	Bacterial;Topoisomerase
Passage	DNA Damage/DNA Repair;Anti-infection
Background	It is a quinolone antibiotic that is a Topoisomerase II inhibitor.
Biological Activity	Flumequine 是一种喹诺酮类抗生素，为Topoisomerase II抑制剂，IC50 值为 15 μM (3.92 μg/mL)[1-3]。
IC50	Topoisomerase II:15μM [1-3]
Data Literature Source	[1]. Kashida Y，et al. Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice. Toxicol Sci. 2002 Oct;69(2):317-21. [2]. Aller-Morán LM，et al. Evaluation of the in vitro activity of flumequine against field isolates of Brachyspira hyodysenteriae. Res Vet Sci. 2015 Dec;103:51-3. [3]. Giraud E，et al. Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol. 2004 Sep;53(Pt 9):895-901.
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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