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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > EtoposideCAS：33419-42-0
Molecular Formula：C29H32O13
Molecular Weight：588.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 33419-42-0 |
| Name | Etoposide |
| Molecular Formula | C29H32O13 |
| Molecular Weight | 588.56 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 251-509-1 |
| MDL | MFCD00869325 |
| SMILES | O=C1OC[C@]2([H])[C@H](O[C@H]3[C@@H]([C@H]([C@@H]4O[C@H](C)OC[C@H]4O3)O)O)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(O)C(OC)=C7)[C@]21[H] |
| InChIKey | VJJPUSNTGOMMGY-MRVIYFEKSA-N |
| InChI | InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1 |
| PubChem CID | 36462 |
| Target Point | Topoisomerase |
| Passage | DNA Damage/DNA Repair |
| Background | Etoposide is an inhibitor of topoisomerase II that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. Etoposide has anti-tumor activity and is a commonly used anti-tumor chemotherapy compound. |
| Biological Activity | Etoposide是用于治疗多种癌症的化疗药物。 Etoposide通过与拓扑异构酶II和DNA形成复合物来抑制DNA合成。[1-3] |
| Data Literature Source | [1]. Lee KI， et al. Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicol In Vitro. 2016 Jul 26. pii: S0887-2333 (16) 30147-3. [2]. Calvani M， det al. Etoposide-Bevacizumab a new strategy against human melanoma cells expressing stem-like traits. Oncotarget. 2016 Jun 9. doi: 10.18632/oncotarget.9939. [3]. Fuchs， J.， et al. Comparative activity of cisplatin， ifosfamide， doxorubicin， carboplatin， and etoposide in heterotransplanted hepatoblastoma. Cancer， 1998. 83 (11) : p. 2400-7. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Li S, et al. Front Cell Dev Biol. 2022 Jan 31;9768123.
Zhang X, et al. J Cell Physiol. 2020 Nov;235(11)8826-8838.
Li S, et al. Front Cell Dev Biol. 2022 Jan 31;9768123.
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