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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > EzetimibeCAS：163222-33-1
Molecular Formula：C24H21F2NO3
Molecular Weight：409.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 163222-33-1 |
| Name | Ezetimibe |
| Molecular Formula | C24H21F2NO3 |
| Molecular Weight | 409.43 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 682-606-0 |
| MDL | MFCD00937872 |
| SMILES | O=C1N(C2=CC=C(F)C=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O |
| InChIKey | OLNTVTPDXPETLC-XPWALMASSA-N |
| InChI | InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1 |
| PubChem CID | 150311 |
| Target Point | Keap1-Nrf2 |
| Passage | NF-κB |
| Background | Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator, and Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. |
| Biological Activity | Ezetimibe 是一种 NPC1L1 抑制剂，是有效的 Nrf2 激活剂，Ezetimibe 是有效的胆固醇吸收抑制剂。[1-2] |
| Data Literature Source | [1]. Lee DH， et al. Ezetimibe， an NPC1L1 inhibitor， is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12; 99:520-532. [2]. Chang E， et al. Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol. 2015 Jul 7; 21 (25) :7754-63 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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