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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > (-)-EpicatechinCAS：490-46-0
Molecular Formula：C15H14O6
Molecular Weight：290.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 490-46-0 |
| Name | (-)-Epicatechin |
| Molecular Formula | C15H14O6 |
| Molecular Weight | 290.27 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-710-1 |
| MDL | MFCD00075648 |
| SMILES | O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1 |
| InChIKey | PFTAWBLQPZVEMU-UKRRQHHQSA-N |
| InChI | InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1 |
| PubChem CID | 72276 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | (-)-Epicatechin inhibits COX-1; inhibits IL-1β-induced iNOS expression by blocking the nuclear localization of the p65 subunit of NF-κB. |
| Biological Activity | (-) -Epicatechin 抑制环加氧酶-1 (COX-1) , IC50为 3.2 μM。 (-) -Epicatechin 通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达[1-3]。 |
| IC50 | COX-1:3.2μM (IC50) [1-3] |
| Data Literature Source | [1]. Waffo-Téguo P， et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001; 40 (2) :173-9. [2]. Shay J， et al. Molecular Mechanisms and Therapeutic Effects of (-) -Epicatechin and Other Polyphenols in Cancer， Inflammation， Diabetes， and Neurodegeneration. Oxid Med Cell Longev. 2015; 2015:181260. [3]. Nogueira L， et al. (-) -Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011 Sep 15; 589 (Pt 18) :4615-31. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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