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My CartCAS：74011-58-8
Molecular Formula：C15H17FN4O3
Molecular Weight：320.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 74011-58-8 |
| Name | Enoxacin |
| Molecular Formula | C15H17FN4O3 |
| Molecular Weight | 320.32 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD00133308 |
| SMILES | O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCNCC3)=N2)C1=O)O |
| InChIKey | IDYZIJYBMGIQMJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23) |
| PubChem CID | 3229 |
| Target Point | Bacterial;Topoisomerase |
| Passage | Anti-infection |
| Background | Enoxacin interferes with DNA replication and inhibits bacterial DNA spinase and topoisomerase IV. Enoxacin is a specific cancer growth inhibitor. Enoxacin is a miRNA processing activator. |
| Biological Activity | Enoxacin (AT 2266)， a fluoroquinolone， interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 μg/ml) and topoisomerase IV (IC50=26.5 μg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin has potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing[1][2][3][4]. |
| IC50 | Quinolone |
| Data Literature Source | [1]. Sonia Melo，et al.Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4394-9. [2]. M Takei，et al. Target preference of 15 quinolones against Staphylococcus aureus，based on antibacterial activities and target inhibition. Antimicrob Agents Chemother. 2001 Dec;45(12):3544-7. [3]. Ge Shan，et al. A small molecule enhances RNA interference and promotes microRNA processing. Nat Biotechnol. 2008 Aug;26(8):933-40. [4]. Rengen Fan，et al. Small molecules with big roles in microRNA chemical biology and microRNA-targeted therapeutics. RNA Biol. 2019 Jun;16(6):707-718. [5]. Chin，N.-X. and H.C. Neu，In vitro activity of enoxacin，a quinolone carboxylic acid，compared with those of norfloxacin，new beta-lactams，aminoglycosides，and trimethoprim. Antimicrobial agents and chemotherapy，1983. 24(5): p. 754-763. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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