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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > Dimethyl FumarateCAS：624-49-7
Molecular Formula：C6H8O4
Molecular Weight：144.13
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 624-49-7 |
| Name | Dimethyl Fumarate |
| Molecular Formula | C6H8O4 |
| Molecular Weight | 144.13 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 210-849-0 |
| MDL | MFCD00064438 |
| SMILES | O=C(OC)/C=C/C(OC)=O |
| InChIKey | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| InChI | InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+ |
| PubChem CID | 637568 |
| Target Point | Keap1-Nrf2 |
| Passage | NF-κB |
| Background | Dimethyl Fumarate is an Nrf2 activator that induces up-regulated expression of antioxidant genes. |
| Biological Activity | Dimethyl fumarate 是一种 Nrf2 激活剂，能够诱导上调抗氧化基因的表达。[1-6] |
| Data Literature Source | [1]. Albrecht P，et al. Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflammation. 2012 Jul 7;9:163 [2]. Peng H，et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26. [3]. Meili-Butz S，et al. Dimethyl fumarate，a small molecule drug for psoriasis，inhibits Nuclear Factor-kappaB and reduces myocardial infarct size in rats. Eur J Pharmacol. 2008 May 31;586(1-3):251-8. [4]. Cross SA，et al. Dimethyl fumarate，an immune modulator and inducer of the antioxidant response，suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15;187(10):5015-25. [5]. Jing X，et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40 [6]. Li Y，et al. Dimethyl fumarate accelerates wound healing under diabetic condition. J Mol Endocrinol. 2018 Jul 23. pii: JME-18-0102. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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