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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > DihydromyricetinCAS：27200-12-0
Molecular Formula：C15H12O8
Molecular Weight：320.25
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 27200-12-0 |
| Name | Dihydromyricetin |
| Molecular Formula | C15H12O8 |
| Molecular Weight | 320.25 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-001-8 |
| MDL | MFCD00189451 |
| SMILES | O=C1[C@H](O)[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13 |
| InChIKey | KJXSIXMJHKAJOD-LSDHHAIUSA-N |
| InChI | InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1 |
| PubChem CID | 161557 |
| Target Point | mTOR |
| Passage | PI3K/Akt/mTOR |
| Background | It is a potent dihydropyrimidase inhibitor. Dihydromyricetin activates autophagy by inhibiting mTOR signaling. Dihydromyricetin inhibits mTOR complex (mTORC1/2) formation. |
| Biological Activity | Dihydromyricetin 是一种有效的二氢嘧啶酶 (dihydropyrimidinase) 抑制剂，IC50 为 48 μM。Dihydromyricetin 可通过抑制 mTOR 信号从而激活自噬。Dihydromyricetin 抑制 mTOR 复合体 (mTORC1/2) 形成。[1-3] |
| IC50 | Dihydropyrimidinase:48μM [1] |
| Data Literature Source | [1]. Huang CY. Inhibition of a Putative Dihydropyrimidinase from Pseudomonas aeruginosa PAO1 by Flavonoids and Substrates of Cyclic Amidohydrolases. PLoS One. 2015 May 19;10(5):e0127634. [2]. Kou X，et al. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTORsignal pathway. Oncotarget. 2016 Nov 15;7(46):74484-74495. [3]. Chang H，et al. Ampelopsin suppresses breast carcinogenesis by inhibiting the mTOR signalling pathway. Carcinogenesis. 2014 Aug;35(8):1847-54. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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