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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Parasite > DihydroartemisininCAS：71939-50-9
Molecular Formula：C15H24O5
Molecular Weight：284.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 71939-50-9 |
| Name | Dihydroartemisinin |
| Molecular Formula | C15H24O5 |
| Molecular Weight | 284.35 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00274495 |
| SMILES | O[C@@H]1[C@H](C)[C@]2([H])CC[C@@H](C)[C@]3([H])CC[C@@](O4)(C)OO[C@]32[C@]4([H])O1 |
| InChIKey | BJDCWCLMFKKGEE-ISOSDAIHSA-N |
| InChI | InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1 |
| PubChem CID | 3000518 |
| Target Point | Parasite;NF-κB |
| Passage | Anti-infection |
| Background | Dihydroartemisin is an effective antimalarial compound. Dihydroartemisini can inhibit NF- κ B activation to induce autophagy and apoptosis. |
| Biological Activity | Dihydroartemisinin是一种有效的抗疟疾 (anti-malaria) 药物。[1-3] |
| IC50 | 33.6 ± 6.8mmol/l(BxPC-3 cells);49.9± 7.0mmol/l(AsPC-1 cells)[4] |
| Data Literature Source | [1]. Hu W，et al. Dihydroartemisinin induces autophagy by suppressing NF-κB activation. Cancer Lett. 2014 Feb 28;343(2):239-48. [2]. Li YJ，et al. Dihydroartemisinin accentuates the anti-tumor effects of photodynamic therapy via inactivation of NF-κB in Eca109 and Ec9706 esophageal cancer cells. Cell Physiol Biochem. 2014;33(5):1527-36. [3]. Li HJ，et al. Dihydroartemisinin-praziquantel combinations and multiple doses of dihydroartemisinin in the treatment of Schistosoma japonicum in experimentally infected mice. Ann Trop Med Parasitol. 2011 Jun;105(4):329-33 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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