{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > DecitabineCAS：2353-33-5
Molecular Formula：C8H12N4O4
Molecular Weight：228.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 2353-33-5 |
| Name | Decitabine |
| Molecular Formula | C8H12N4O4 |
| Molecular Weight | 228.21 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 219-089-4 |
| MDL | MFCD00043011 |
| SMILES | O=C1N=C(N)N=CN1[C@H](O[C@@H]2CO)C[C@@H]2O |
| InChIKey | XAUDJQYHKZQPEU-KVQBGUIXSA-N |
| InChI | InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1 |
| PubChem CID | 451668 |
| Target Point | DNA Methyltransferase |
| Passage | Epigenetics |
| Background | Decitabine is an orally active DNA methyltransferase inhibitor. Incorporation of Decitabine instead of DNA into cytosine can covalently capture DNA methyltransferase into DNA， resulting in irreversible inhibition of the enzyme. Decitabine induces cell G2/M block and apoptosis， and has effective anticancer activity. |
| Biological Activity | Decitabine (NSC 127716) 是一种DNA甲基转移酶抑制剂，通常用于治疗骨髓增生异常综合征(MDS) 和急性髓性白血病 (AML)。[1-5] |
| Data Literature Source | 1]. Nakamura M，et al. Decitabine inhibits tumor cell proliferation and up-regulates E-cadherin expression in Epstein-Barr virus-associated gastric cancer. J Med Virol. 2016 Jul 19. [2]. Zhang C，et al. Quantitative proteomic analysis of histone modifications in decitabine sensitive and resistant leukemia cell lines. Clin Proteomics. 2016 Jul 5;13:14. [3]. Requena CE，et al. The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabine. Biochem J. 2016 Jun 20. [4]. Terse P，et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33(2):75-85. [5]. Yu J，et al. DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine. J Clin Invest. 2018 Jun 1;128(6):2376-2388. |
| Unit | Bottle |
| Specification | 1mg 5mg 10mM*1mL in DMSO 10mg 25mg 50mg 100mg 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Experimental DNA Demethylation Reduces Expression Plasticity and Thermal Tolerance in Pacific Oysters
Click to check >>Author：Wang Xinxing, Cong Rihao, Li Ao, Wang Wei, Zhang Guofan, Li Li
IF：3.7270
Publish_to：MARINE BIOTECHNOLOGY
PMID：37079122
Manual Download
