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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > CyclopamineCAS：4449-51-8
Molecular Formula：C27H41NO2
Molecular Weight：411.62
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 4449-51-8 |
| Name | Cyclopamine |
| Molecular Formula | C27H41NO2 |
| Molecular Weight | 411.62 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01735266 |
| SMILES | CC1=C2[C@@]([C@@]3([H])[C@]([C@@]4(C(C[C@@H](O)CC4)=CC3)C)([H])C2)([H])CC[C@@]15[C@@H]([C@@]6([H])[C@](C[C@H](C)CN6)([H])O5)C |
| InChIKey | QASFUMOKHFSJGL-LAFRSMQTSA-N |
| InChI | InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1 |
| PubChem CID | 442972 |
| Target Point | Hedgehog/Smoothened |
| Passage | Hedgehog;Stem Cells |
| Background | Cyclopamine is a specific Hedgehog signaling pathway antagonist |
| Biological Activity | Cyclopamine 是 Hedgehog 通路的拮抗剂, 在细胞实验中的 IC50 为 46 nM[1]。 |
| IC50 | IC50: 46nM (Hedgehog， in Hh cell assay) [1] |
| Data Literature Source | [1]. Peukert S， et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway. Bioorg Med Chem Lett， 2009， 19 (2) ， 328-331. [2]. Berman DM， et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature， 2003， 425 (6960) ， 846-851. [3]. Thayer SP， et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature， 2003， 425 (6960) ， 851-856. [4]. Ma W， et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20; 45 (5) :237-246 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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ANP reduced Hedgehog signaling-mediated activation of matrix metalloproteinase-9 in gastric cancer cell line MGC-803
Click to check >>Author：Li CH; Liu M; Pan LH; Sun Y
IF：3.5000
Publish_to：Gene
PMID：32777528
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