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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > CurcuminCAS：458-37-7
Molecular Formula：C21H20O6
Molecular Weight：368.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 458-37-7 |
| Name | Curcumin |
| Molecular Formula | C21H20O6 |
| Molecular Weight | 368.38 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-280-5 |
| MDL | MFCD00008365 |
| SMILES | O=C(CC(/C=C/C1=CC=C(O)C(OC)=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2 |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| InChI | InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ |
| PubChem CID | 969516 |
| Target Point | P300/CREB;Histone acetyltransferase (HAT);Keap1-Nrf2 |
| Passage | Epigenetics;NF-κB |
| Background | Curcumin is a specific inhibitor of acetyltransferase p300/CREB binding protein that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin can inhibit NF-κb and MAPKs, and has anti-inflammatory, antioxidant, anti-angiogenesis and other physiological activities. |
| Biological Activity | Curcumin是一种天然酚类化合物，具有抗炎，抗氧化，抗增殖和抗血管生成等多种活性。 Curcumin是p300组蛋白乙酰转移酶 ((HATs)) 抑制剂，也显示对 NF-κB 和MAPKs 的抑制作用。[1-6] |
| Data Literature Source | [1]. Gao S，et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway，promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Jul 18. pii: S0278-6915(13)004 [2]. Nasiri M，et al. Curcumin and Silibinin Inhibit Telomerase Expression in T47D Human Breast Cancer Cells. Asian Pac J Cancer Prev. 2013;14(6):3449-53. [3]. Cao A，et all. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 2013 Jul 24. [Epub ahead of print] [4]. Jiang H，et al. Antidepressant-like effects of curcumin in chronic mild stress of rats: Involvement of its anti-inflammatory action. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 20. pii: S0278-5846(13)00150-4. [5]. Guo H，et al. Curcumin induces cell cycle arrest and apoptosis of prostate cancer cells by regulating the expression of IkappaBalpha，c-Jun and androgen receptor. Pharmazie. 2013 Jun;68(6):431-4. [6]. Zhu X，et al. Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS One. 2014 Mar 6;9(3):e91303. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Jia W, et al. Biomed Pharmacother. 2019 Mar;111:1204-1212.
Zhang Z, et al. Biomed Res Int. 2019 Oct 31;2019:8912961.
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Targeting transportation of curcumin by soybean lipophilic protein nano emulsion: Improving its bioaccessibility and regulating intestinal microorganisms in mice
Click to check >>Author：Zhen Zeng, Siqi Deng, Yang Liu, Cheng Li, Zhengfeng Fang, Bin Hu, Hong Chen, Caixia Wang, Saiyan Chen, Wenjuan Wu, Yuntao Liu
IF：11.5040
Publish_to：FOOD HYDROCOLLOIDS
PMID：
Improved water solubility,antioxidant,and sustained-release properties of curcumin through the complexation with soy protein fibrils
Click to check >>Author：Fuyun Ji, Jingjing Xu, Huihui Liu, Dongliang Shao, Chuyan Wang, Yanyan Zhao, Shuizhong Luo, Xiyang Zhong, Zhi Zheng
IF：6.0560
Publish_to：LWT-FOOD SCIENCE AND TECHNOLOGY
PMID：
Understanding molecular interaction between thermally modified β-lactoglobulin and curcumin by multi-spectroscopic techniques and molecular dynamics simulation
Click to check >>Author：Ru Zhao, Yingcong Lu, Ce Wang, Xiaoge Zhang, Abbas Khan, Cuina Wang
IF：5.9990
Publish_to：COLLOIDS AND SURFACES B-BIOINTERFACES
PMID：37178459
Extrusion-based 3D printing of pickering high internal phase emulsions stabilized by flaxseed protein-sodium alginate complexes for encapsulating curcumin
Click to check >>Author：Yan Chen, Yu-Sheng Wang, Ying-Hui Li, Zi-Yan Li, Yun-Zhen Ma, Xiao-Yi Qin, Hai-Hua Chen
IF：5.2000
Publish_to：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
PMID：
Curcumin Inhibits ERK/c-Jun Expressions and Phosphorylation against Endometrial Carcinoma
Click to check >>Author：Zhang Z; Yi P; Tu C; Zhan J; Jiang L; Zhang F
IF：3.2460
Publish_to：Biomed Res Int
PMID：32083122
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