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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > CoptisineCAS：3486-66-6
Molecular Formula：C19H14NO4
Molecular Weight：320.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 3486-66-6 |
| Name | Coptisine |
| Molecular Formula | C19H14NO4 |
| Molecular Weight | 320.32 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00867219 |
| SMILES | C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6 |
| InChIKey | XYHOBCMEDLZUMP-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1 |
| PubChem CID | 72322 |
| Target Point | Indoleamine 2,3-Dioxygenase (IDO) |
| Passage | Immunology & Inflammation;Metabolic Enzyme&Protease |
| Background | Coptisine is a potent and noncompetitive IDO inhibitor. |
| Biological Activity | Coptisine 是从黄连中分离到的生物碱，是一种有效的非竞争性的 IDO 抑制剂，Ki 值为 5.8 μM，IC50 值为 6.3 μM[1-2]。 |
| Data Literature Source | [1]. He K，et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94. [2]. Rao PC，et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Antibacterial activity mechanism of coptisine against Pasteurella multocida
Click to check >>Author：Zhang Rui, Tian Shuo, Zhang Tengfei, Zhang Wenting, Lu Qin, Hu Qiao, Shao Huabin, Guo Yunqing, Luo Qingping
IF：5.7000
Publish_to：Frontiers in Cellular and Infection Microbiology
PMID：37502603
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