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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Cichoric AcidCAS：6537-80-0
Molecular Formula：C22H18O12
Molecular Weight：474.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 6537-80-0 |
| Name | Cichoric Acid |
| Molecular Formula | C22H18O12 |
| Molecular Weight | 474.37 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22683653 |
| SMILES | O=C(O)[C@H](OC(/C=C/C1=CC=C(O)C(O)=C1)=O)[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C(O)=O |
| InChIKey | YDDGKXBLOXEEMN-IABMMNSOSA-N |
| InChI | InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1 |
| PubChem CID | 5281764 |
| Target Point | Reactive oxygen species (ROS) |
| Passage | Immunology & Inflammation |
| Background | Cichoric Acid is a dicaffeinated tartaric acid with anti-diabetic and antioxidant and anti-inflammatory activities. |
| Biological Activity | Chicoric acid (Cichoric acid)， an orally active dicaffeyltartaric acid， induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake， improves insulin resistance， and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant， anti-inflammatory effects[1-3]. |
| Data Literature Source | [1]. Haifang Xiao，et al. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. J Agric Food Chem. 2013 Feb 20;61(7):1509-20. [ [2]. Di Zhu，et al. Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells. J Agric Food Chem. 2015 Dec 30;63(51):10903-13. [3]. Di Zhu，et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017 Sep;107(Pt A):138-149 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Effects of Torulaspora delbrueckii on physicochemical properties and volatile flavor compounds of navel orange wine
Click to check >>Author：Jingjing Liu, Yin Wan, Yanru Chen, Mengxiang Li, Na Liu, Huibo Luo, Dan Huang, Hong Peng, Guiming Fu
IF：4.5200
Publish_to：JOURNAL OF FOOD COMPOSITION AND ANALYSIS
PMID：
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