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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > CelecoxibCAS：169590-42-5
Molecular Formula：C17H14F3N3O2S
Molecular Weight：381.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 169590-42-5 |
| Name | Celecoxib |
| Molecular Formula | C17H14F3N3O2S |
| Molecular Weight | 381.37 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 685-962-5 |
| MDL | MFCD00941298 |
| SMILES | CC1=CC=C(C=C1)C2=CC(C(F)(F)F)=NN2C3=CC=C(C=C3)S(=O)(N)=O |
| InChIKey | RZEKVGVHFLEQIL-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) |
| PubChem CID | 2662 |
| Target Point | COX-2 |
| Passage | Immunology & Inflammation |
| Background | It is a selective COX-2 inhibitor that inhibits prostaglandin production by inhibiting COX-2. |
| Biological Activity | Celecoxib 是一种选择性的 COX-2 抑制剂, IC50 为 40 nM[1-5]。 |
| IC50 | COX-2:40nM (IC50) COX-1:15μM (IC50) [1-5] |
| Data Literature Source | [1]. Penning TD， et al. Synthesis and biological evaluation of the 1，5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5- (4-methylphenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl]benze nesulfonamide (SC-58635， celecoxib) . J Med Chem. 1997 [2]. Liu DB， et al. Celecoxib induces apoptosis and cell-cycle arrest in nasopharyngeal carcinoma cell lines via inhibition of STAT3 phosphorylation. Acta Pharmacol Sin. 2012 May; 33 (5) :682-90. [3]. Suri A， et al. The effect of celecoxib on tumor growth in ovarian cancer cells and a genetically engineered mouse model of serous ovarian cancer. Oncotarget. 2016 Apr 8. [4]. Hou XL， et al. Combination of fasudil and celecoxib promotes the recovery of injured spinal cord in rats better than celecoxib or fasudil alone. Neural Regen Res. 2015 Nov; 10 (11) :1836-40. [5]. Liu C， et al. Celecoxib alleviates nonalcoholic fatty liver disease by restoring autophagic flux. Sci Rep. 2018 Mar 7; 8 (1) :4108. |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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