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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BezafibrateCAS：41859-67-0
Molecular Formula：C19H20ClNO4
Molecular Weight：361.82
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 41859-67-0 |
| Name | Bezafibrate |
| Molecular Formula | C19H20ClNO4 |
| Molecular Weight | 361.82 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 255-567-9 |
| MDL | MFCD00078970 |
| SMILES | CC(C)(OC1=CC=C(CCNC(C2=CC=C(Cl)C=C2)=O)C=C1)C(O)=O |
| InChIKey | IIBYAHWJQTYFKB-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24) |
| PubChem CID | 39042 |
| Target Point | PPAR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | Bezafibrate is a PPAR agonist. |
| Biological Activity | Bezafibrate 是 PPAR 的激动剂，对于小鼠PPARα，PPARγ和PPARδ，EC50分别为90μM，55μM，110μM，对于人PPARα，PPARγ和PPARδ分别为50μM，60μM，20μM；Bezafibrate 是一种降血脂剂。[1-3] |
| Data Literature Source | [1]. Willson TM，et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [2]. Usui-Ouchi A，et al. The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells. Int Immunopharmacol. 2017 Nov;52:70-76. [3]. Franko A，et al. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol Metab. 2017 Jan 6;6(3):256-266. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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