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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Atractylenolide ICAS：73069-13-3
Molecular Formula：C15H18O2
Molecular Weight：230.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 73069-13-3 |
| Name | Atractylenolide I |
| Molecular Formula | C15H18O2 |
| Molecular Weight | 230.3 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09037395 |
| SMILES | O=C1C(C)=C(C[C@@]23[H])C(O1)=C[C@@]3(C)CCCC2=C |
| InChIKey | ZTVSGQPHMUYCRS-SWLSCSKDSA-N |
| InChI | InChI=1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h8,12H,1,4-7H2,2-3H3/t12-,15+/m0/s1 |
| PubChem CID | 5321018 |
| Target Point | Toll-like Receptor (TLR) |
| Passage | Immunology & Inflammation |
| Background | Atractylenolide I, a sesquiterpene, is an antagonist of TLR4 with neuroprotective, antiallergic, anti-inflammatory and anticancer activities. |
| Biological Activity | Atractylenolide I 具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。Atractylenolide I 为 TLR4 的拮抗剂，同时在 A375 细胞中，能够降低 JAK2 和 STAT3 的磷酸化水平。[1-4] |
| Data Literature Source | [1]. Atractylenolide I， et al. The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I. Exp Dermatol. 2018 Feb; 27 (2) :201-204. [2]. Gao H， et al. Anti-depressant-like effect of atractylenolide I in a mouse model of depression induced by chronic unpredictable mild stress. Exp Ther Med. 2018 Feb; 15 (2) :1574-1579. [3]. Li W， et al. Atractylenolide I restores HO-1 expression and inhibits Ox-LDL-induced VSMCs proliferation， migration and inflammatory responses in vitro. Exp Cell Res. 2017 Apr 1; 353 (1) :26-34. [4]. Huang JM， et al. Atractylenolide-I sensitizes human ovarian cancer cells to paclitaxel by blocking activation of TLR4/MyD88-dependent pathway. Sci Rep. 2014 Jan 23; 4:3840. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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