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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Acetylsalicylic acidCAS：50-78-2
Molecular Formula：C9H8O4
Molecular Weight：180.16
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 50-78-2 |
| Name | Acetylsalicylic acid |
| Molecular Formula | C9H8O4 |
| Molecular Weight | 180.16 |
| Solubility | Soluble in DMSO/Ethanol ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-064-1 |
| MDL | MFCD00002430 |
| SMILES | OC(C1=C(OC(C)=O)C=CC=C1)=O |
| InChIKey | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) |
| PubChem CID | 2244 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Acetylsalicylic acid is a derivative of salicylic acid and an irreversible COX1 and COX2 inhibitor. |
| Biological Activity | Aspirin是非选择性和不可逆的 COX-1 和 COX-2 抑制剂，IC50 分别为5，210 μg/mL。Aspirin 和其他非类固醇抗炎药物可抑制环氧合酶（COX）的活性，从而导致前列腺素（PGs）的形成，引起炎症，肿胀，疼痛和发烧。[1-5] |
| Data Literature Source | [1]. Mitchell JA，et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [2]. Vane JR，et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8. [3]. Wu KK，et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12. [4]. Kopp E，et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9. [5]. Blanco FJ，et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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