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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ApigeninCAS：520-36-5
Molecular Formula：C15H10O5
Molecular Weight：270.24
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 520-36-5 |
| Name | Apigenin |
| Molecular Formula | C15H10O5 |
| Molecular Weight | 270.24 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-292-3 |
| MDL | MFCD00006831 |
| SMILES | OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1 |
| InChIKey | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
| PubChem CID | 5280443 |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | Apigenin is a competitive CYP2C9 inhibitor. |
| Biological Activity | Apigenin 是一种竞争性 CYP2C9 抑制剂，Ki 为 2 μM。[1-3] |
| IC50 | Ki: 2μM(CYP2C9)[1] |
| Data Literature Source | [1]. Si D，et al. Mechanism of CYP2C9 inhibition by flavones and flavonols. Drug Metab Dispos. 2009 Mar;37(3):629-34. [2]. Wu K，et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11(29):4461-4. [3]. Yu W，et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676 |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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