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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > AndrographolideCAS：5508-58-7
Molecular Formula：C20H30O5
Molecular Weight：350.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 5508-58-7 |
| Name | Andrographolide |
| Molecular Formula | C20H30O5 |
| Molecular Weight | 350.45 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 226-852-5 |
| MDL | MFCD07778082 |
| SMILES | O=C1OC[C@@H](O)/C1=C\C[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C |
| InChIKey | BOJKULTULYSRAS-OTESTREVSA-N |
| InChI | InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1 |
| PubChem CID | 5318517 |
| Target Point | NF-kB |
| Passage | NF-κB |
| Background | Andrographolide is an NF-κB inhibitor that inhibits NF-κB activation by covalently modifying the cysteine residue of p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. |
| Biological Activity | Andrographolide 是一种 NF-κB 抑制剂，通过共价修饰内皮细胞中 p50 的半胱氨酸残基而抑制 NF-κB 活化，而不影响 IκBα 降解或 p50/p65 核易位。[1] |
| Data Literature Source | [1]. Zhai ZJ，et al. Andrographolide suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. Br J Pharmacol. 2014 Feb;171(3):663-75 |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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