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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > 5-Aminosalicylic AcidCAS：89-57-6
Molecular Formula：C7H7NO3
Molecular Weight：153.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to brown Solid
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| CAS | 89-57-6 |
| Name | 5-Aminosalicylic Acid |
| Molecular Formula | C7H7NO3 |
| Molecular Weight | 153.14 |
| Solubility | Soluble in DMSO ≥2mg/mL ;Soluble in Water ≥10mg/mL(Need ultrasonic or add HCl to help dissolve) |
| Purity | HPLC≥98% |
| Appearance | Off-white to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 201-919-1 |
| MDL | MFCD00007877 |
| SMILES | OC1=C(C(O)=O)C=C(N)C=C1 |
| InChIKey | KBOPZPXVLCULAV-UHFFFAOYSA-N |
| InChI | InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11) |
| PubChem CID | 4075 |
| Target Point | PPAR;PAK1;NF-κB |
| Passage | Cell Cycle; DNA Damage/DNA Repair; Cytoskeleton; NF-κB |
| Background | 5-Aminosalicylic Acid is a specific PPARγ agonist that also inhibits p21-activated kinase 1 (PAK1) and NF-κB. |
| Biological Activity | 5-Aminosalicylic acid 是一种特异性的 PPARγ 激动剂，还抑制 p21-激活激酶1 (PAK1) 和 NF-κB。[1-3] |
| Data Literature Source | [1]. Dammann K， et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct; 1853 (10 Pt A) :2349-60. [2]. Fang HM， et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28; 13 (20) :2872-7. [3]. Rousseaux C， et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov; 34 (11) :2580-6. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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