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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AdapaleneCAS：106685-40-9
Molecular Formula：C28H28O3
Molecular Weight：412.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 106685-40-9 |
| Name | Adapalene |
| Molecular Formula | C28H28O3 |
| Molecular Weight | 412.52 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 620-513-9 |
| MDL | MFCD03106112 |
| SMILES | O=C(C1=CC2=CC=C(C3=CC=C(OC)C(C45C[C@@H](C[C@H](C6)C5)C[C@@H]6C4)=C3)C=C2C=C1)O |
| InChIKey | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
| InChI | InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30) |
| PubChem CID | 60164 |
| Target Point | RAR |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a retinoic acid receptor (RAR) agonist. |
| Biological Activity | Adapalene (CD271)， a third-generation synthetic retinoid， is widely used for the research of acne. Adapalene is a potent RAR agonist， with AC50s of 2.3 nM， 9.3 nM， and 22 nM for RARβ， RARγ， RARα， respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1-3]. |
| IC50 | AC50: 2.3nM(RARβ)，9.3nM(RARγ)，and 22nM(RARα)[1] |
| Data Literature Source | [1]. Shroot B，et，al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun;36(6 Pt 2):S96-103. [2]. Wang Q，et，al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec;93:103315. [3]. Shi XN，et，al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov;12(5):6501-8. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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