{{cart_num}}
My CartCAS：1005780-62-0
Molecular Formula：C23H23N7O3
Molecular Weight：445.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
Qty：
Size：
| CAS | 1005780-62-0 |
| Name | TAK-593 |
| Molecular Formula | C23H23N7O3 |
| Molecular Weight | 445.47 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | PDGFR;VEGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | TAK-593 is a potent inhibitor of VEGFR2 and PDGFR. |
| Biological Activity | TAK-593 is a potent VEGFR and PDGFR family inhibitor with IC50s of 3.2， 0.95， 1.1， 4.3 and 13 nM for VEGFR1， VEGFR2， VEGFR3， PDFGRα and PDFGRβ， respectively.[1-2] |
| Data Literature Source | [1]. Miyamoto N， et al. Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1，2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1，3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593)， a highly potent VEGFR2 kinase inhibitor. Bioorg Med Chem. 2013 Apr 15;21(8):2333-2345. [2]. Awazu Y， et al. Anti-angiogenic and anti-tumor effects of TAK-593， a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase. Cancer Sci. 2013 Apr;104(4):486-94. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no experimental images.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
