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My CartCAS：957135-43-2
Molecular Formula：C62H84N14O6
Molecular Weight：1121.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 957135-43-2 |
| Name | SM-164 |
| Molecular Formula | C62H84N14O6 |
| Molecular Weight | 1121.42 |
| Solubility | Soluble in DMSO ≥2mg/mL |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | XIAP |
| Passage | Apoptosis |
| Background | SM-164 is a potent， non-peptide， cell-permeable antagonist of XIAP that targets the BIR2 and BIR3 domains. |
| Biological Activity | SM-164 is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.[1-2] |
| Data Literature Source | [1]. Sun H， et al. Design， synthesis， and characterization of a potent， nonpeptide， cell-permeable， bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J Am Chem Soc. 2007 Dec 12;129(49):15279-94. [2]. Lu J， et al. SM-164: a novel， bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68(22):9384-93. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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