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My CartCAS：1197996-80-7
Molecular Formula：C21H24N2O2
Molecular Weight：336.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 1197996-80-7 |
| Name | CBL0137 |
| Molecular Formula | C21H24N2O2 |
| Molecular Weight | 336.43 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Target Point | FACT |
| Passage | Others |
| Background | CBL0137 is a histone chaperone promoting chromatin transcription (FACT) inhibitor. |
| Biological Activity | CBL0137， a curaxin compound， is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-?B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis.[1-3] |
| Data Literature Source | [1]. Barone TA， et al. Anticancer drug candidate CBL0137， which inhibits histone chaperone FACT， is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma. Neuro Oncol. 2017 Feb 1;19(2):186-196. h [2]. Burkhart C， et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5(22):11038-53. [3]. Ehteda A， et al. Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG. Cell Rep. 2021 Apr 13;35(2):108994. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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