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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > PreladenantCAS：377727-87-2
Molecular Formula：C25H29N9O3
Molecular Weight：503.56
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 377727-87-2 |
| Name | Preladenant |
| Molecular Formula | C25H29N9O3 |
| Molecular Weight | 503.56 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | COCCOC1=CC=C(C=C1)N2CCN(CC2)CCN3C4=C(C=N3)C5=NC(=NN5C(=N4)N)C6=CC=CO6 |
| InChIKey | DTYWJKSSUANMHD-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7，14，17H，8-13，15-16H2，1H3，(H2，26，29) |
| PubChem CID | 10117987 |
| Target Point | Adenosine Receptor |
| Passage | GPCR & G Protein |
| Background | Preladenant is a potent, competitive human adenosine A2A receptor antagonist. |
| Biological Activity | Preladenant is a potent and competitive antagonist of the human adenosine A2A receptor with a Ki of 1.1 nM and has over 1000-fold selectivity over other adenosine receptors.[1-2] |
| IC50 | Ki: 1.1 nM (Adenosine A2A receptor)[1] |
| Data Literature Source | [1]. Hodgson RA， et al. Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2，4-difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4，3-e][1，2，4]triazolo[1，5-c]pyrimidin-5-amine] in rodent [2]. Hodgson RA， et al. Preladenant， a selective A(2A) receptor antagonist， is active in primate models of movement disorders. Exp Neurol. 2010 Oct;225(2):384-90. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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